Familial aggregation of phenotypic expression of premature hair hypopigmentation in the craniofacial region

Autores

  • Corey Black University of Pittsburgh

DOI:

https://doi.org/10.5195/d3000.2015.31

Palavras-chave:

Premature hypopigmentation, gray hair, hair color, male, tobacco, genetic, shaft, follicle, human, adolescent, melanocyte, melanin, stem cells

Resumo

There are many patients who experience premature hypopigmentation of hair, but do not understand the underlying causes and potential dangers associated with them. The causes range from genetic predisposition to environmental influences such as tobacco use. Premature hypopigmentation of the hair shaft can also be associated with many syndromes; some which cause dental anomalies. Today, treatment options are limited for patients, although various studies are being done on mice to target the underlying mechanism of action. Understanding the differences between all of the possible causes of this particular phenotype can help clinicians better identify the symptoms, educate patients, and possibly modify treatment to suit the needs of each patient on an individual basis.

Referências

Epidemiological and investigative study of premature graying of hair in higher secondary and pre-university school children. Bhat RM, Sharma R, Pinto AC, Dandekeri S, Martis J. Int J Trichology. 2013 Jan;5(1):17-21. doi: 10.4103/0974-7753.114706. PMID:23960391

Tobin, D. & Trueb, R. (2010). Nat-ural Hair Graying. In Aging Hair (pp. 208-210). New York, New York: Springer Science & Business Media.

The hair follicle and its stem cells as drug delivery targets. Hoffman RM. Expert Opin Drug Deliv. 2006 May;3(3):437-43. Review. PMID:16640502

Polymorphisms in the syntaxin 17 gene are not associated with human cutaneous malignant mela-noma. Zhao ZZ, Duffy DL, Thomas SA, Martin NG, Hayward NK, Mont-gomery GW. Melanoma Res. 2009 Apr;19(2):80-6. doi: 10.1097/CMR.0b013e328322fc45. PMID:19209086

Premature hair graying: a proba-ble coronary risk factor. Gould L, Reddy CV, Oh KC, Kim SG, Becker W. Angiology. 1978 Nov;29(11):800-3. PMID:727561

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Publicado

2015-04-07

Edição

v. 3 n. 1 (2015)

Seção

Adults & the Elderly

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