Familial aggregation of phenotypic expression of premature hair hypopigmentation in the craniofacial region

Autor/innen

  • Corey Black University of Pittsburgh

DOI:

https://doi.org/10.5195/d3000.2015.31

Schlagworte:

Premature hypopigmentation, gray hair, hair color, male, tobacco, genetic, shaft, follicle, human, adolescent, melanocyte, melanin, stem cells

Abstract

There are many patients who experience premature hypopigmentation of hair, but do not understand the underlying causes and potential dangers associated with them. The causes range from genetic predisposition to environmental influences such as tobacco use. Premature hypopigmentation of the hair shaft can also be associated with many syndromes; some which cause dental anomalies. Today, treatment options are limited for patients, although various studies are being done on mice to target the underlying mechanism of action. Understanding the differences between all of the possible causes of this particular phenotype can help clinicians better identify the symptoms, educate patients, and possibly modify treatment to suit the needs of each patient on an individual basis.

Literaturhinweise

Epidemiological and investigative study of premature graying of hair in higher secondary and pre-university school children. Bhat RM, Sharma R, Pinto AC, Dandekeri S, Martis J. Int J Trichology. 2013 Jan;5(1):17-21. doi: 10.4103/0974-7753.114706. PMID:23960391

Tobin, D. & Trueb, R. (2010). Nat-ural Hair Graying. In Aging Hair (pp. 208-210). New York, New York: Springer Science & Business Media.

The hair follicle and its stem cells as drug delivery targets. Hoffman RM. Expert Opin Drug Deliv. 2006 May;3(3):437-43. Review. PMID:16640502

Polymorphisms in the syntaxin 17 gene are not associated with human cutaneous malignant mela-noma. Zhao ZZ, Duffy DL, Thomas SA, Martin NG, Hayward NK, Mont-gomery GW. Melanoma Res. 2009 Apr;19(2):80-6. doi: 10.1097/CMR.0b013e328322fc45. PMID:19209086

Premature hair graying: a proba-ble coronary risk factor. Gould L, Reddy CV, Oh KC, Kim SG, Becker W. Angiology. 1978 Nov;29(11):800-3. PMID:727561

Downloads

Veröffentlicht

2015-04-07

Ausgabe

Bd. 3 Nr. 1 (2015)

Rubrik

Adults & the Elderly

Lizenz

Authors who publish with this journal agree to the following terms:

  1. The Author retains copyright in the Work, where the term “Work” shall include all digital objects that may result in subsequent electronic publication or distribution.
  2. Upon acceptance of the Work, the author shall grant to the Publisher the right of first publication of the Work.
  3. The Author shall grant to the Publisher and its agents the nonexclusive perpetual right and license to publish, archive, and make accessible the Work in whole or in part in all forms of media now or hereafter known under a Creative Commons Attribution 4.0 International License or its equivalent, which, for the avoidance of doubt, allows others to copy, distribute, and transmit the Work under the following conditions:
    1. Attribution—other users must attribute the Work in the manner specified by the author as indicated on the journal Web site;
    with the understanding that the above condition can be waived with permission from the Author and that where the Work or any of its elements is in the public domain under applicable law, that status is in no way affected by the license.
  4. The Author is able to enter into separate, additional contractual arrangements for the nonexclusive distribution of the journal's published version of the Work (e.g., post it to an institutional repository or publish it in a book), as long as there is provided in the document an acknowledgement of its initial publication in this journal.
  5. Authors are permitted and encouraged to post online a prepublication manuscript (but not the Publisher’s final formatted PDF version of the Work) in institutional repositories or on their Websites prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work. Any such posting made before acceptance and publication of the Work shall be updated upon publication to include a reference to the Publisher-assigned DOI (Digital Object Identifier) and a link to the online abstract for the final published Work in the Journal.
  6. Upon Publisher’s request, the Author agrees to furnish promptly to Publisher, at the Author’s own expense, written evidence of the permissions, licenses, and consents for use of third-party material included within the Work, except as determined by Publisher to be covered by the principles of Fair Use.
  7. The Author represents and warrants that:
    1. the Work is the Author’s original work;
    2. the Author has not transferred, and will not transfer, exclusive rights in the Work to any third party;
    3. the Work is not pending review or under consideration by another publisher;
    4. the Work has not previously been published;
    5. the Work contains no misrepresentation or infringement of the Work or property of other authors or third parties; and
    6. the Work contains no libel, invasion of privacy, or other unlawful matter.
  8. The Author agrees to indemnify and hold Publisher harmless from Author’s breach of the representations and warranties contained in Paragraph 6 above, as well as any claim or proceeding relating to Publisher’s use and publication of any content contained in the Work, including third-party content.

Revised 7/16/2018. Revision Description: Removed outdated link.