Correlation between a VEGF Marker and Patients with Mucoepidermoid Carcinoma

Autores

  • Asmaa H. Ali Ministry of Higher education and Scientific Research Al-Fallujah University College of Medicine Department of Anatomy

DOI:

https://doi.org/10.5195/d3000.2025.1038

Palavras-chave:

Carcinoma, Cancer, Oral Medicine

Resumo

Objective: The aim of this work was to examine the expression of VEGF and its correlation with the grade of mucoepidermoid carcinoma.

Subjectss and Methods: A cohort of 17 males with mean age 47.1+/-13.15 and 13 females with mean age 38.65+/-22.15 was studied. Eight cases had high, 11 moderate, and 11 had low grade lesions based on histophatology. Fifty formalin-fixed, paraffin-embedded tissue blocks of these patients with mucoepidermoid disease were used to confirm the diagnosis in this study using sections stained with hematoxylin and eosin.

Results: VEGF was expressed in all cases. Cytoplasmic expression varied from +1 in two cases to +4 in 28 cases. VEGF was expressed at high intensity in 27 cases. A significant difference (P < 0.05) was found between the intensity and expression of VEGF, according to the chi-square test. There was a significant correlation between mucoepidermoid carcinoma and grade of cancer.

Conclusion: VEGF was expressed in malignant tumors and may serve as a marker for the disease.

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Publicado

2025-10-08

Edição

v. 13 n. 1 (2025)

Seção

Adults & the Elderly

Licença

Copyright (c) 2025 Asmaa H. Ali

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