Antifungal Effect and Softness of Denture Tissue Conditioner Incorporated with Chitosan

نویسندگان

  • Omar A. Sheet Department of Prosthodontics, College of Dentistry, University of Mosul, Iraq
  • Abdullah J. Mohammed
  • Ahmad A. Saeed
  • Maha A. Al-Rejaboo

DOI::

https://doi.org/10.5195/d3000.2026.1400

کلمات کلیدی:

Nystatin, Dentures, Candida albicans, Stomatitis

چکیده

Tissue conditioners treated oral candidiasis as a cushioning material. Adding Nystatin to the tissue conditioner was one of the treatment plans for treating such cases. Due to their biocompatibility and antimicrobial abilities, chitosan has become one of the promising materials in the treatment of fungal infections. Ninety-two samples were constructed from the tissue conditioner. They were divided into six groups: G1 tissue conditioner without additions, G2 with 3.2% Nystatin addition, G3 with chitosan addition 5%, G4 with chitosan addition 7%, G5 with Nystatin 3.2% and chitosan 5%, G6 with 3.2% Nystatin and chitosan 7%. Two tests were accomplished: the disc diffusion test for fungal inhibition capacity and the hardness test. Statistical analyses were made using ANOVA and Duncan’s test using SPSS 18. The results showed that the samples in group G6 had significantly the highest inhibition efficiency without compromising the resilience property of the tissue conditioner, the hardness test showed that the addition of Nystatin and chitosan did not affect the resilience property of the tissue conditioner, also showed that the hardness of the tissue conditioner was increased significantly after seven days. The addition of the Nystatin 3.2% and chitosan 7% demonstrated the most superior inhibition efficacy in one and seven days compared to other groups, including the control group, indicating successful sustained release of Nystatin in addition to the fortified inhibition in the presence of chitosan. The hardness test showed no effect of the added materials on the resilience of the tissue conditioner. The tissue conditioner should be replaced preferably after seven days due to its loss of resilience and intended cushioning ability.

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چاپ شده

2026-06-16

شماره

دوره 14 شماره 1 (2026)

نوع مقاله

Infancy & Adolescence

مجوز

حق نشر 2026 Omar A. Sheet, Abdullah J. Mohammed, Ahmad A. Saeed, Maha A. Al-Rejaboo

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