Comparative evaluation of Indocyanine Green and 810nm Diode Laser Assisted Antimicrobial Photodynamic Therapy with 810nm Diode Laser Assisted New Attachment Procedure as adjuncts to Scaling and Root Planning in Supportive Periodontal Therapy: A Randomized Controlled Split-Mouth Clinical Trial
DOI:
https://doi.org/10.5195/d3000.2024.392Λέξεις-κλειδιά:
Indocyanine Green, Laser, Photodynamic therapy, Periodontitis, Periodontal attachment lossΠερίληψη
BACKGROUND: Minimally invasive nonsurgical management of recurrent periodontal pockets remains the most viable option during supportive periodontal therapy (SPT), but with inconclusive results. The purpose of this study is to evaluate and compare the adjunctive use of Indocyanine green (ICG) and 810nm Diode laser assisted photodynamic therapy (IG-PDT) with 810nm Diode laser assisted new attachment procedure (LANAP) in the management of persistent pockets in SPT.
MATERIALS AND METHODS: This single blinded randomized controlled split mouth clinical trial included 20 participants with at least two adjacent teeth with PPD ≥5mm and Clinical attachment level (CAL) ≥3mm in the contralateral quadrants. IG-PDT group received application of 5mg/ml solution of ICG for one minute followed by 810±10nm diode laser with 1W power density. LANAP group received 810±10nm diode laser application at 3W power density with 100ms and 650ms pulse duration at two consecutive passes. Clinical parameters i.e., Plaque index (PI), Gingival index (GI), PPD, CAL gain were recorded at baseline, 3 and 6 months. Landry’s Healing index was assessed on the 7th day and 1 month postoperatively. Patient comfort was assessed using Visual Analog Scale (VAS) immediate post-operatively.
RESULTS: Student t test and repeated measures of ANOVA were used for statistical analysis. Both site level and patient level assessments of clinical parameters showed improvement in clinical parameters in both groups. However, IG-PDT group showed significantly greater improvements in PPD (<0.001) and CAL (<0.001) at 3 and 6 months evaluation. IG-PDT showed better healing (P-0.03) at 7th post-operative day. However, LANAP showed less discomfort (2.40±0.50) compared to IG-PDT group (3.20±0.61).
CONCLUSION: IG-PDT is shown to provide better clinical outcomes compared to LANAP in management of patients under SPT.
Αναφορές
Könönen E, Gursoy M, Gursoy UK. Periodontitis: A Multifaceted Disease of Tooth-Supporting Tissues. J Clin Med. 8 (8) (2019) 1135, https:// doi.org/ 10.3390/jcm8081135.
Heitz-Mayfield LJ, Trombelli L, Heitz F, Needleman I, Moles D. A systematic review of the effect of surgical debridement vs non-surgical debridement for the treatment of chronic periodontitis. J Clin Periodontol. 29 (3) (2002) 92-102, https://doi.org/ 10.1034/j.1600-051x.29.s3.5.x.
Hirata T, Fuchida S, Yamamoto T, Kudo C, Minabe M. Predictive factors for tooth loss during supportive periodontal therapy in patients with severe periodontitis: a Japanese multicenter study. BMC oral health. 19 (19) (2019), https://doi.org/10.1186/s12903-019-0712-x.
Atarbashi-Moghadam F, Talebi M, Mohammadi F, Sijanivandi S. Recurrence of periodontitis and associated factors in previously treated periodontitis patients without maintenance follow-up. J Adv Periodontol Implant Dent. 12 (2) (2020) 79-83, https://doi.org/10.34172/japid.2020.010.
Sanz-Martín I, Cha JK, Yoon SW, Sanz-Sánchez I, Jung UW. Long-term assessment of periodontal disease progression after surgical or non-surgical treatment: a systematic review. J Periodontal Implant Sci. 49 (2) (2019) 60-75, https://doi.org/10.5051/jpis.2019.49.2.60.
Mombelli A. Maintenance therapy for teeth and implants. Periodontol 2000. 79 (1) (2019) 190-199, https://doi.org/10.1111/prd.12255.
Mikami R, Mizutani K, Sasaki Y, Iwata T, Aoki A. Patient-reported outcomes of laser-assisted pain control following non-surgical and surgical periodontal therapy: A systematic review and meta-analysis. PLoS One. 15 (9) (2020) e0238659, https://doi.org/10.1371/journal.pone.0238659.
Suprith S, Setty S, Thakur S. Diode Laser as an Adjunctive to Nonsurgical Periodontal Therapy during Maintenance Phase: A Randomized Controlled Clinical Trial. Int J Laser Dent 6 (1) (2016) 12-17, https://doi.org/10.5005/jp-journals-10022-1080.
Ratka-Krüger P, Mahl D, Deimling D, Mönting JS, Jachmann I, Al-Machot E, Sculean A, Berakdar M, Jervøe-Storm PM, Braun A. Er:YAG laser treatment in supportive periodontal therapy. J Clin Periodontol. 39 (5) (2012) 483-489, https//doi.org/10.1111/j.1600-051X.2012.01857.x.
Choi E, Um HS, Chang BS, Lee SY, Lee JK. Clinical and microbiological effects of adjunctive local delivery of minocycline (Periocline®) in patients receiving supportive periodontal therapy: a pilot study. J Periodontal Implant Sci. 51 (1) (2021) 53-62, https://doi.org/10.5051/jpis.2002720136.
Manresa C, Sanz-Miralles EC, Twigg J, Bravo M. Supportive periodontal therapy (SPT) for maintaining the dentition in adults treated for periodontitis. Cochrane Database Syst Rev. 1 (1) (2018) CD009376, https://doi.org/10.1002/14651858.CD009376.
Cobb CM, Low SB, Coluzzi DJ. Lasers and the treatment of chronic periodontitis. Dent Clin North Am. 54 (1) (2010) 35-53, https://doi.org/10.1016/j.cden.2009.08.007.
Noguchi T, Sanaoka A, Fukuda M, Suzuki S, Aoki T. Combined effects of Nd:YAG laser irradiation with local antibiotic application into periodontal pockets. J Int Acad Periodontol. 7 (1) (2005) 8-15, PMID: 15736890.
Schwarz F, Aoki A, Sculean A, Becker J. The impact of laser application on periodontal and peri-implant wound healing. Periodontol 2000. 51 (2009) 79-108, htpps://doi.org/10.1111/j.1600-0757.2009.00301.x.
Kim I S, Cho T H, Kim K, Weber F E and Hwang S J. High power pulsed Nd:YAG laser as a new stimulus to induce BMP-2 expression in MC3T3–E1 osteoblasts Lasers. Surg. Med. 42 (2010) 510–518.
Harris DM, Gregg RH, McCarthy DK, Colby LE, Tilt LV. Laser-assisted new attachment procedure in private practice. General Dentistry. 52 (5) (2004) 396-403.
Nevins ML, Camelo M, Schupbach P, Kim SW, Kim DM, Nevins M. Human clinical and histologic evaluation of laser-assisted new attachment procedure. Int J Periodontics Restorative Dent,32 (2012) 497–507. PMID: 22754897
Yukna RA, Carr RL, Evans GH. Histologic evaluation of an Nd:YAG laser-assisted new attachment procedure in humans. Int J Periodontics Restorative Dent. 27 (6) (2007) 577-587, PMID: 18092452.
Jha A, Gupta V, Adinarayan R. LANAP, periodontics and beyond: a review. J Lasers Med Sci. 9 (2) (2018) 76- 81, https://doi.org/10.15171/jlms.2018.16.
Niemz MH. Laser-tissue interaction. Fundamentals and applications. Berlin: Springer-Verlag, (1996) 58-87, https://doi.org/10.1007/978-3-662-03193-3.
Kolbe MF, Ribeiro FV, Luchesi VH, Casarin RC, Sallum EA, Nociti FH Jr, Ambrosano GM, Cirano FR, Pimentel SP, Casati MZ. Photodynamic therapy during supportive periodontal care: clinical, microbiologic, immunoinflammatory, and patient-centered performance in a split-mouth randomized clinical trial. J Periodontol. 85 (8) (2014) e277-286, https://doi.org/ 10.1902/jop.2014.130559.
Park, D., Choi, E. J., Weon, K.-Y., Lee, W., Lee, S. H., Choi, J.-S., … Choi, J. W. Non-Invasive Photodynamic Therapy against -Periodontitis-causing Bacteria. Scientific Reports, 9 (1) (2019), https://doi.org/10.1038/s41598-019-44498-4.
Fan Z, Zong J, Lau WY, Zhang Y. Indocyaninee green and its nanosynthetic particles for the diagnosis and treatment of hepatocellular carcinoma. Am J Transl Res.12 (6) (2020) 2344-2352. PMID: 32655776; PMCID: PMC7344064.
Alander JT, Kaartinen I, Laakso A, Pätilä T, Spillmann T, Tuchin VV, Venermo M, Välisuo P. A review of indocyaninee green fluorescent imaging in surgery. Int J Biomed Imaging. (2012) 940585, https://doi.org/10.1155/2012/940585.
Sevieri M, Silva F, Bonizzi A, Sitia L, Truffi M, Mazzucchelli S, Corsi F. Indocyaninee Green Nanoparticles: Are They Compelling for Cancer Treatment? Front Chem. 8 (2020) 535, https://doi.org/10.3389/fchem.2020.00535.
Raut CP, Sethi KS, Kohale BR, Mamajiwala A, Warang A. Indocyaninee green-mediated photothermal therapy in treatment of chronic periodontitis: A clinico-microbiological study. J Indian Soc Periodontol. 22 (2018) 221-227, https://doi.org/10.4103/jisp.jisp_128_18.
Papapanou PN, Sanz M, Buduneli N, Dietrich T, Feres M, Fine DH, et al. Periodontitis: Consensus report of workgroup 2 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions. J Periodontol. 89 (1) (2018) 173-182, https://doi.org/10.1002/JPER.17-0721.
Löe H. The Gingival Index, the Plaque Index and the Retention Index Systems. J Periodontol. 38 (6) (1967) 610-616, https://doi.org/10.1902/jop.1967.38.6.610.
Lingamaneni S, Mandadi LR, Pathakota KR. Assessment of healing following low-level laser irradiation after gingivectomy operations using a novel soft tissue healing index: A randomized, double-blind, splitmouth clinical pilot study. J Indian Soc Periodontol. 23 (2019) 53-57, https://doi.org/10.4103/jisp.jisp_226_18.
Masse JF, Landry RG, Rochette C, Dufour L, Morency R, D'Aoust P. Effectiveness of soft laser treatment in periodontal surgery. Int Dent J. 43 (2) (1993) 121-127, PMID: 8320005.
Koppolu P, Mishra A, Swapna LA, Butchibabu K, Bagalkokar A, Baroudi K. Comparison of efficacy among various topical anesthetics: An approach towards painless injections in periodontal surgery. Saudi J Anaesth. 10 (1) (2016) 55-7, https://doi.org/10.4103/1658-354X.169476.
AlSarhan MA, Altammami MA, Alaqeely RS, AlEbdi A, Jasser RA, Otaibi DA, et al. Short-term improvement of clinical parameters and microbial diversity in periodontitis patients following Indocyaninee green-based antimicrobial photodynamic therapy: A randomized single-blind split-mouth cohort. Photodiagnosis Photodyn Ther. 35 (2021) 102349, https://doi.org/10.1016/j.pdpdt.2021.102349.
Kirpalani T, Dym H. Role of Piezo Surgery and Lasers in the Oral Surgery Office. Dent Clin North Am. 64 (2) (2020) 351-363, https://doi.org/10.1016/j.cden.2019.12.007.
Christodoulides N, Nikolidakis D, Chondros P, Becker J, Schwarz F, Rössler R, Sculean A. Photodynamic therapy as an adjunct to non-surgical periodontal treatment: a randomized, controlled clinical trial. J Periodontol. 79 (9) (2008) 1638-1644, https://doi.org/10.1902/jop.2008.070652.
Joshi K, Baiju CS, Khashu H, Bansal S. Clinical effectiveness of indocyaninee green mediated antimicrobial photodynamic therapy as an adjunct to scaling root planing in treatment of chronic periodontitis- A randomized controlled clinical trial. Photodiagnosis Photodyn Ther.29 (2020) 101591. https://doi.org/10.1016/j.pdpdt.2019.101591.
McCawley TK, McCawley MN, Rams TE. Immediate effect of Nd:YAG laser monotherapy on subgingival periodontal pathogens: a pilot clinical study. J Periodontal Implant Sci. 52 (1) (2020) 77-87, https://doi.org//10.5051/jpis.2100900045.
Müller Campanile VS, Giannopoulou C, Campanile G, Cancela JA, Mombelli A. Single or repeated antimicrobial photodynamic therapy as adjunct to ultrasonic debridement in residual periodontal pockets: clinical, microbiological, and local biological effects. Lasers Med Sci. 30 (1) (2015) 27-34, https://doi.org/10.1007/s10103-013-1337-y.
Bashir NZ, Singh HA, Virdee SS. Indocyanine green-mediated antimicrobial photodynamic therapy as an adjunct to periodontal therapy: a systematic review and meta-analysis. Clin Oral Investig. 25 (10) (2021) 5699-5710, https://doi.org/10.1007/s00784-021-03871-2.
Sufaru IG, Martu MA, Luchian I, Stoleriu S, Diaconu-Popa D, Martu C, Teslaru S, Pasarin L, Solomon SM. The Effects of 810 nm Diode Laser and Indocyanine Green on Periodontal Parameters and HbA1c in Patients with Periodontitis and Type II Diabetes Mellitus: A Randomized Controlled Study. Diagnostics (Basel). 12 (7) (2022) 1614, https://doi.org/10.3390/diagnostics12071614.
Parker S. The use of diffuse laser photonic energy and indocyanine green photosensitizer as an adjunct to periodontal therapy. Br Dent J. 215 (2013) 167–171, https://doi.org/10.1038/sj.bdj.2013.790.
Benson RC, Kues HA. Fluorescence properties of indocyanine green as related to angiography. Phys Med Biol. 23 (1978) 159–163, https://doi.org/10.1088/0031-9155/23/1/017.
Takasaki AA, Aoki A, Mizutani K, et al. Application of antimicrobial photodynamic therapy in periodontal and peri-implant diseases. Periodontol 2000. 51 (2009) 109–140, https://doi.org/10.1111/j.1600-0757.2009.00302.x.
Topaloglu N, Gulsoy M, Yuksel S. Antimicrobial photodynamic therapy of resistant bacterial strains by indocyanine green and 809-nm diode laser. Photomed Laser Surg. 31 (2013) 155–162, https://doi.org/10.1089/pho.2012.3430.
Dalvi S, Khetal N, Ansari S, Benedicenti S, Hanna R. Utilization of 810 nm Diode Laser Treatment in Periodontitis as an Alternative to Surgical Debridement Approach. Photochem Photobiol. 97 (3) (2021) 566-573, https://doi.org/10.1111/php.13417.
Nevins M, Kim SW, Camelo M, Martin IS, Kim D, Nevins M. A prospective 9-month human clinical evaluation of Laser-Assisted New Attachment Procedure (LANAP) therapy. Int J Periodontics Restorative Dent. 34 (1) (2014) 21-7, https://doi.org/10.11607/prd.1848.
Tuby H, Maltz L, Oron U. Modulations of VEGF and iNOS in the rat heart by low level laser therapy are associated with cardioprotection and enhanced angiogenesis. Lasers Surg Med. 38 (7) (2006) 682-688, https://doi.org/10.1002/lsm.20377.
Camachoa AD, Paredesb AC, Aldana RL. An in vitro study of the reaction of periodontal and gingival fibroblasts to low‑level laser irradiation: A Pilot Study. J Oral Laser Appl. 8 (2008) 235-244.
Aoki A, Mizutani K, Schwarz F, Sculean A, Yukna RA, Takasaki AA, Romanos GE, Taniguchi Y, Sasaki KM, Zeredo JL, Koshy G, Coluzzi DJ, White JM, Abiko Y, Ishikawa I, Izumi Y. Periodontal and peri-implant wound healing following laser therapy. Periodontol 2000. 68 (1) (2015) 217-69, https://doi.org/10.1111/prd.12080.
Srikanth K, Chandra RV, Reddy AA, Reddy BH, Reddy C, Naveen A. Effect of a single session of antimicrobial photodynamic therapy using indocyanine green in the treatment of chronic periodontitis: a randomized controlled pilot trial. Quintessence Int. 46 (5) (2015) 391-400, https://doi.org/10.3290/j.qi.a33532.
Atieh MA. Photodynamic therapy as an adjunctive treatment for chronic periodontitis: a meta-analysis. Lasers Med Sci. 25 (4) (2010) 605-613, https://doi.org/10.1007/s10103-009-0744-6.
Chondros P, Nikolidakis D, Christodoulides N, Rössler R, Gutknecht N, Sculean A. Photodynamic therapy as adjunct to non-surgical periodontal treatment in patients on periodontal maintenance: a randomized controlled clinical trial. Lasers Med Sci.24 (5) (2009) 681-698, https://doi.org/10.1007/s10103-008-0565-z.
Lulic M, LeiggenerGörög I, Salvi GE, Ramseier CA, Mattheos N, Lang NP. One-year outcomes of repeated adjunctive photodynamic therapy during periodontal maintenance: a proof-of-principle randomized-controlled clinical trial. J Clin Periodontol. 36 (8) (2009) 661-666, https://doi.org/10.1111/j.1600-051X.2009.01432.x.
Mongardini C, Di Tanna GL, Pilloni A. Light-activated disinfection using a light-emitting diode lamp in the red spectrum: clinical and microbiological short-term findings on periodontitis patients in maintenance. A randomized controlled split-mouth clinical trial. Lasers Med Sci. 29 (1) (2014) 1-8, https://doi.org/10.1007/s10103-012-1225-x.
Λήψεις
Δημοσιευμένα
Τεύχος
Ενότητα
Άδεια
Πνευματική ιδιοκτησία (c) 2024 Sruthima NVS Gottumukkala, Sathya Valli Veluri, Gautami Subhadra Penmetsa, Ramesh KSV, Mohan Kumar Pasupuleti, Dinesh Gera, Sravanthi Vundavalli
Αυτή η εργασία είναι αδειοδοτημένη υπό το CC Αναφορά Δημιουργού 4.0.
Authors who publish with this journal agree to the following terms:
- The Author retains copyright in the Work, where the term “Work” shall include all digital objects that may result in subsequent electronic publication or distribution.
- Upon acceptance of the Work, the author shall grant to the Publisher the right of first publication of the Work.
- The Author shall grant to the Publisher and its agents the nonexclusive perpetual right and license to publish, archive, and make accessible the Work in whole or in part in all forms of media now or hereafter known under a Creative Commons Attribution 4.0 International License or its equivalent, which, for the avoidance of doubt, allows others to copy, distribute, and transmit the Work under the following conditions:
- Attribution—other users must attribute the Work in the manner specified by the author as indicated on the journal Web site;
- The Author is able to enter into separate, additional contractual arrangements for the nonexclusive distribution of the journal's published version of the Work (e.g., post it to an institutional repository or publish it in a book), as long as there is provided in the document an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post online a prepublication manuscript (but not the Publisher’s final formatted PDF version of the Work) in institutional repositories or on their Websites prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work. Any such posting made before acceptance and publication of the Work shall be updated upon publication to include a reference to the Publisher-assigned DOI (Digital Object Identifier) and a link to the online abstract for the final published Work in the Journal.
- Upon Publisher’s request, the Author agrees to furnish promptly to Publisher, at the Author’s own expense, written evidence of the permissions, licenses, and consents for use of third-party material included within the Work, except as determined by Publisher to be covered by the principles of Fair Use.
- The Author represents and warrants that:
- the Work is the Author’s original work;
- the Author has not transferred, and will not transfer, exclusive rights in the Work to any third party;
- the Work is not pending review or under consideration by another publisher;
- the Work has not previously been published;
- the Work contains no misrepresentation or infringement of the Work or property of other authors or third parties; and
- the Work contains no libel, invasion of privacy, or other unlawful matter.
- The Author agrees to indemnify and hold Publisher harmless from Author’s breach of the representations and warranties contained in Paragraph 6 above, as well as any claim or proceeding relating to Publisher’s use and publication of any content contained in the Work, including third-party content.
Revised 7/16/2018. Revision Description: Removed outdated link.
