Comparison of the Effect of Ketorolac and Betamethasone Injection on Post Complications of Third Molar Surgery (A Clinical Trial)
DOI:
https://doi.org/10.5195/d3000.2024.513Schlagworte:
Ketorolac, Injection, Masseter Muscle, Betamethasone LA, Third molar surgeryAbstract
BACKGROUND: The aim of this study was to evaluate the effect of preoperative ketorolac and betamethasone injections on reducing postoperative complications mandibular third molar surgery.
MATERIALS AND METHODS: In this randomized clinical trial, 134 patients at the age group of 18-40 years who required mandibular molars surgery were studied. Patients were randomly divided into two groups. In A group, 1 mL of betamethasone LA was injected into the master muscle before surgery, and in the A group, 30 mg of ketorolac per 1 mL was injected before surgery. On the second and seventh days after surgery, patients were evaluated for the variables of maximum mouth opening, pain, swelling, and general satisfaction with the surgery through telephone calls on the second and seventh days. Independent t-test and Mann-Whitney test were used to evaluate the variables.
RESULTS: The mean of pain intensity and the swelling variables in the betamethasone group were lower than the ketorolac group in second and seventh days (P<0.05). The mean of maximum mouth opening and the patient satisfaction variables in the betamethasone group were higher than the ketorolac group in second day (P<0.05). There was no statistically significant difference in the patient satisfaction and maximum mouth opening variables on the seventh day (P>0.05).
CONCLUSION: This study concluded that betamethasone performed significantly better in reducing swelling, pain, maximum mouth opening limitation, and general satisfaction.
Literaturhinweise
Comparison of the Effectiveness of Dexamethasone Injection into Two Different Sites in Preventing the Postoperative Complications after Mandibular Third Molar Surgery: A Randomized Clinical Trial. Shirani M, Hasanzade M, Moadabi A, Attar B. Br J Med Med Res 2016; 13(10), 1–11. http://dx.doi.org/10.9734/BJMMR/2016/23638.
Clinical postoperative findings after removal of impacted mandibular third molars: Prediction of postoperative facial swelling and pain based on preoperative variables. Yuasa H, Sugiura M. British Journal of Oral and Maxillofacial Surgery 2004;42(3),209-14. https://doi.org/10.1016/j.bjoms.2004.02.005.
Psychological aspects of pain. Gorczyca R, Filip R, Walczak E. Ann Agric Environ Med 2013, 20(1), 23–7. PMID: 25000837.
The use of corticosteroids and nonsteroidal antiinflammatory medication for the management of pain and inflammation after third molar surgery: A review of the literature. Kim K, Brar P, Jakubowski J, Kaltman S, Lopez E.. Oral Surg, Oral Med Oral Pathol Oral Radiol Endododed 2009,10(5), 630–40. https://doi.org/10.1016/j.tripleo.2008.11.005.
Pimenta L, Peterson LJ, Ellise E, Hupp JR TM. Contemporary Oral & Maxillofacial Surgery 4th Edition. Mosby, St. Louis Craniofacial and Dental Developmental Defects: Diagnosis and Management 2003. 113–124.
Submucosal dexamethasone injection improves quality of life measures after third molar surgery: A comparative study. Majid OW, Al-Mashhadani BA. J Oral Maxillofac Surg 2011,69(9),289–97. https://doi.org/10.1016/j.joms.2011.01.037.
The impact of third molar symptoms, pain, and swelling on oral health-related quality of life. Slade GD, Foy SP, Shugars DA, Phillips C, White RP. J Oral Maxillofac Surg2004,62(9),1118-1124. https://doi.org/10.1016/j.joms.2003.11.014.
Complications of Third Molar Surgery. Bouloux GF, Steed MB, Perciaccante VJ. Oral and Maxillofac Surg Clin North Am 2007,19(1),117–28. https://doi.org/10.1016/j.coms.2006.11.013
Beneficial effect of methylprednisolone after mandibular third molar surgery: A randomized, double-blind, placebo-controlled split-mouth trial. Acham S, Klampfl A, Truschnegg A, Kirmeier R, Sandner-Kiesling A, Jakse N. Clin Oral Investig, 2013,17(7)1693–700. https://doi.org/10.1007/s00784-012-0867-1.
Randomized Controlled Trial to Evaluate the Efficacy of Oral Dexamethasone and Intramuscular Dexamethasone in Mandibular Third Molar Surgeries. Sabhlok S, Kenjale P, Mony D, Khatri I, Kumar P. J Clin Diagn Res 2015,9(11), ZC48-5 https://doi.org/10.7860%2FJCDR%2F2015%2F13930.6813.
Do Corticosteroids Still Have a Role in the Management of Third Molar Surgery? Advances in Therapy. Ngeow WC, Lim D. Springer Healthcare; 2016,33(7)1105–1139. https://doi.org/10.1007/s12325-016-0357-y.
Betamethasone and methylprednisolone usage in lower third molar surgery : Review literature. Gozali P, Kiattavornchareon S, Wu M, Wongsirichat N, Suphangul S. M Dent J 2015,35(3),273–80.
Corticosteroids reduce postoperative morbidity after third molar surgery: A systematic review and meta-analysis. Markiewicz MR,Brady MF, Ding EL, Dodson TB. J Oral Maxillofac Surg 2008,66(9), 1881-94. https://doi.org/10.1016/j.joms.2008.04.022.
Analgesic Efficacy of Paracetamol Vs Ketorolac after Dental Extractions. Rao TD, Kumar MPS. Res J Pharm Technol. 2018,11(8),3375-9. http://dx.doi.org/10.5958/0974-360X.2018.00621.2
Comparison of the anti-inflammatory effect of dexamethasone and ketorolac in the extractions of third molars. Paiva-Oliveira J, Bastos P, Pontes E, Silva J, Delgado J, Oshiro-Filho N. Oral Maxillofac Surg 2016,20(2), 123-33. https://doi.org/10.1007/s10006-015-0533-2.
Efficacy of sub-mucosal, intra-masseteric and intra-muscular routes of dexamethasone administration on post-operative complications following impacted mandibular third molar surgeries, comparative clinical trial. Mahmoud N. Egyptian Dental Journal 2019,65(1), 113–33. https://dx.doi.org/10.21608/edj.2015.71254.
Comparison of Efficacy of Methylprednisolone Injection into Masseter Muscle Versus Gluteal Muscle for Surgical Removal of Impacted Lower Third Molar. Selvaraj L, Hanumantha Rao S, Lankupalli ASMaxillofac Oral Surge. 2014,13(4), 495–8. https://doi.org/10.1007/s12663-013-0562-z.
Efficacy of methylprednisolone injected into the masseter muscle following the surgical extraction of impacted lower third molars. Vegas-Bustamante E, Micó-Llorens J, Gargallo-Albiol J, Satorres-Nieto M, Berini-Aytés L, Gay-Escoda C. Int J Oral Maxillofac Surge2008,37(3),260–3. https://doi.org/10.1016/j.ijom.2007.07.018.
Effect of Submucosal Injection of Dexamethasone on Postoperative Discomfort After Third Molar Surgery: A Prospective Study. Grossi GB, Maiorana C, Garramone RA, Borgonovo A, Beretta M, Farronato D, et al. J Oral Maxillofac Surg. 2007,65(11), 2218–26. https://doi.org/10.1016/j.joms.2006.11.036.
Comparison of Efficacy of Methylprednisolone Injection into Masseter Muscle Versus Gluteal Muscle for Surgical Removal of Impacted Lower Third Molar. Selvaraj L, Hanumantha Rao S, Lankupalli AS. J MaxillofacOral Surg,2014,13(4), 495–8. https://doi.org/10.1007/s12663-013-0562-z.
Post-operative pain and inflammatory reaction reduced by injection of a corticosteroid. A controlled trial in bilateral oral surgery. Skjelbred P, Loekken P, Løkken P. Eur J Clin Pharmacol ,1982,21(5), 391–6. https://doi.org/10.1007/BF00542325.
Comparison of Intramuscular Ketorolac Tromethamine and Morphine Sulfate for Analgesia of Pain After Major SurgeryPharmacother.Yee JP, Koshiver JE, Allbon C, Brown CR. J Hum Pharmacol Drug Ther 1986,6(5), 253–61. https://doi.org/10.1002/j.1875-9114.1986.tb03485.x.
Comparative Evaluation of Pre-Emptive Analgesic Efficacy of Intramuscular Ketorolac Versus Tramadol Following Third Molar Surgery. Shah A V., Arun Kumar K V., Rai KK, Rajesh Kumar BP. J Maxillofac Oral Surg 2013,12(2), 197–202. https://doi.org/10.1007/s12663-012-0420-4.
How well do clinicians estimate third molar extraction difficulty? Susarla SM, Dodson TB. J Oral Maxillofa Surg 2005,63(2), 191-9. https://doi.org/10.1016/j.joms.2004.05.220.
Winter GB: Principles of exodontias as applied to the impacted third molar 1ed. St. Louis American medical books 1926. In Contemporary Oral and Maxillofacial Sugery. 2th edition. Edited by: Peterson LJ, Ellis E, Hupp JR, Tucker MR. Mosby, St Louis;1993:225-260.
Visual analogue scale assessment of postoperative swelling: A study of clinical inflammatory variables subsequent to third-molar surgery. Berge TI. Acta Odontol Scand 1988,2 6(4), 233–40. https://doi.org/10.3109/00016358809004772.
The use of a visual analogue scale in observer assessment of postoperative swelling subsequent to third-molar surgery. Berge TI. Acta Odontol Scand1989,47(3),167–74. https://doi.org/10.3109/00016358909007697.
Primary and secondary closure of the surgical wound after removal of impacted mandibular third molars: A comparative study. Pasqualini D, Cocero N, Castella A, Mela L, Bracco P. Int J Oral Maxillofac Surg 2005,34(1),52–7. https://doi.org/10.1016/j.ijom.2004.01.023.
Effect of the local administration of betamethasone on pain, swelling and trismus after impacted lower third molar extraction. A randomized, triple blinded, controlled trial. Marques J, Pié-Sánchez J, Figueiredo R, Valmaseda-Castellón E, Gay-Escoda C. Med Oral Patol Oral Cir Bucal 2014,19(1),e49-54. https://doi.org/10.4317/medoral.19280.
Effect of Preoperative Single Dose Dexamethasone Injection in Masseter Muscle on Postoperative Sequelae Following Lower Impacted Third Molar Surgery. Moghadasi M, Golestaneh A, Ghodosi A, Golestani SJ Isfahan Dent Sch 2021 Apr 10,17(1), 87–94 .https://doi.org/10.18502/ijds.v17i1.5919.
The use of intraoral dexamethasone after extraction of mandibular third molars. Messer EJ, Keller JJ. Oral Surgery, Oral Med Oral Pathol1975,4(5),594–8. https://doi.org/10.1016/0030-4220(75)90369-2.
Evaluation of pain, swelling and trismus after extraction of impacted third molars relative to the use of betamethasone in submucusal infiltration. Bertossi D, Donadello D, Ricciardi G, Luciano U, Zotti F, Nocini R, et al. J Biol Regul Homeost Agents 2019 20;33:9–17. PMID: 30966728.
A randomized, double-blind, placebo-controlled study comparing the efficacy and safety of paracetamol, serratiopeptidase, ibuprofen and betamethasone using the dental impaction pain model. Chopra D, Rehan HS, Mehra P, Kakkar AK. Int J Oral Maxillofac Surg 2009,38(4),350–5. https://doi.org/10.1016/j.ijom.2008.12.013.
Is dexamethasone superior to ketorolac in reducing pain, swelling and trismus following mandibular third molar removal? A split mouth triple-blind randomized clinical trial. Martins-De-barros AV, Barros AMI, de Siqueira AKC, Lucena EE de S, de Souza PHS, Araújo FA da C. Med Oral Patol Oral Cir Bucal 2021,26(2),141–50. https://doi.org/10.4317/medoral.24088.
Randomized Controlled Trial Comparing the Effects of 2 Analgesic Drug Protocols in Patients who Received 5 Dental Implants. Meta IF, Bermolen M, MacChi R, Aguilar J. Implant Dent. 2017,26(3)3,412–6. 10.1097/ID.0000000000000544.
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