Mandibular Bone Regeneration Following Maxillofacial Surgical Defects

Forfattere

  • Saif Nabil Jawad
  • Hussain Falh Ali Department of Dental Basic Science / College of Dentistry / Gilgamesh University/ Baghdad, Iraq. College of Medicine, Ibn Sina University of Medical and Pharmaceutical Sciences, Baghdad, Iraq.
  • Haydar Munir Salih

DOI:

https://doi.org/10.5195/d3000.2026.1361

Nøgleord:

Mandible, Rabbit, Oral Surgery

Resumé

This study aimed to quantitatively evaluate mandibular bone regeneration in veterinary rabbit models following experimentally induced maxillofacial defects using clinical and numerical healing parameters. An experimental in vivo study was conducted using 24 healthy adult rabbits randomly divided into three groups: control group, bone graft group, and platelet-rich fibrin (PRF) group. Standardized mandibular bone defects measuring 5 mm in diameter were surgically created under general anesthesia. Clinical healing evaluation, inflammatory scoring, and quantitative bone regeneration measurements were recorded at 2, 4, and 8 weeks postoperatively. Statistical analysis was performed using repeated-measures ANOVA and Tukey post hoc tests with significance set at p < 0.05. PRF group had significantly higher bone healing scores and better quantitative bone regeneration values than control group (p < 0.05). The healing results were also better in the bone graft group, but not as significant as in the PRF group. All groups experienced a gradual decrease in inflammatory scores during the experiment. Experimental mandibular defects created in rabbits showed successful regeneration of the bone. PRF demonstrated better regenerative effect and healing results than the traditional healing process. The quantitative clinical assessment methods were able to evaluate the progression of bone healing without a histological evaluation.

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Publiceret

2026-06-05

Nummer

Årg. 14 Nr. 1 (2026)

Sektion

Infancy & Adolescence

Licens

Copyright (c) 2026 Saif Nabil Jawad, Hussain Falh Ali, Haydar Munir Salih

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