Non-syndromic oral clefts and risk of cancer: a systematic review

Forfattere

  • Daniela Araújo Veloso Popoff State University of Montes Claros
  • Mateus Prates Coelho State University of Montes Claros
  • Daniella Reis Barbosa Martelli State University of Montes Claros
  • Rajiv Saini Rural Dental College
  • Ricardo Della Coletta University of Campinas
  • Hercílio Martelli-Júnior State University of Montes Claros

DOI:

https://doi.org/10.5195/d3000.2013.11

Nøgleord:

Cleft lip and palate, cancer, family studies.

Resumé

Objective: To discuss the risk of cancer among relatives of individuals with cleft lip and palate (CL/P), as well as the risk of CL/P among relatives of individuals with cancer, since studies published currently have suggested  an increased risk of cancer among relatives of cleft individuals. Design: A systematic literature review was carried out in accordance with the Cochrane Collaboration Group protocol, including literature search strategy, selection of papers through the inclusion and exclusion criteria, data extraction and quality assessment. PubMed, Scopus and ISI - Web of Science databases were systematically searched using the fallowing search strings: “cleft lip and palate” AND “cancer”, “oral clefts” AND “cancer” and “orofacial clefts” AND “cancer”. Results: From 653 studies accessed, 8 comprised the final sample: 6 investigating CL/P index cases and their family history of cancer and 2 investigating individuals with cancer and their family history for CL/P. The sample sizes were not homogeneous. Oral clefts, the type of cancer and the degree of kinship family were not categorized in all studies. Leukemia, breast cancer and colon cancer were the most cited types, even as first-and-second degree relatives. Conclusions: An increased risk of cancer among relatives of cleft individuals could not be entirely confirmed. However, studies with this specific purpose suggest that first-and-second degrees relatives of cleft individuals have some types of cancer more often than unexposed families, highlighting that future studies should expand their samples to investigate possible common molecular mechanisms that allow relating oral clefts and cancer.

Forfatterbiografier

Daniela Araújo Veloso Popoff, State University of Montes Claros

Department of Dentistry, professor

Mateus Prates Coelho, State University of Montes Claros

Department of Medicine, graduate student

Daniella Reis Barbosa Martelli, State University of Montes Claros

Department of Dentistry, professor

Rajiv Saini, Rural Dental College

Department of Periodontology and Oral Implantology, professor

Ricardo Della Coletta, University of Campinas

Department of Oral Diagnosis, professor

Hercílio Martelli-Júnior, State University of Montes Claros

Department of Dentistry

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Publiceret

2013-08-23

Nummer

Sektion

Mechanisms of Oral Disease