Comparative analysis of serum titanium level in patient with healthy dental implant and patients with peri-implantitis- A cross sectional prospective study
DOI:
https://doi.org/10.5195/d3000.2024.594Klíčová slova:
Dental implants, Serum titanium, Peri-implantitis, Titanium alloys, Inductively coupled plasma–mass spectroscopyAbstrakt
Objectives: Titanium dental implants can last for more than two decades in the oral environment. Corrosion of the implant surface can release metallic particles or ions into surrounding tissue. The metallic constituents like titanium in human blood serum have not been fully studied. The study compares titanium serum levels before and after dental implant placement and compares levels in patients with healthy implants and those with per-implantitis.
Methods: The study comprised 2groups of Group 1 patient observing implant surgery and group 2 patients with diagnosed peri-implantitis. Each group comprised of 60 patients. Serum titanium level was measured from blood obtained from Group 1 at three different intervals (one month prior to implant surgery, 4th and 8th month after successful loading) and from Group 2 during the course of peri-implantitis by inductively coupled plasma–mass spectroscopy. The statistical analysis was done for the obtained data.
Results: Analysis showed a raised level of serum titanium at 4th month of post implant placement (2.39 mg/dl) and in patient with peri-implantitis(2.94 mg/dl) and both levels are significantly differ (ANOVA test) from pre-surgical estimation of serum titanium level (1.79 mg/dl).
Conclusions: Understanding the correlation between titanium corrosion and peri-implantitis is vital for enhancing the long-term success and safety of dental implants. Additional research is required to investigate these links and potential strategies to protect the well-being of implant patients.
Reference
- Microbial Biofilm Decontamination on Dental implant Surfaces: A Mini Review. Dhaliwal JS, AbdRahman NA, Ming LC, Dhaliwal SKS, Knights J, Albuquerque Junior RF. Front. Cell. Infect. Microbiol. 2021, 11:736186.
- Immunological Aspects of Dental Implant Rejection. Baseri M, Radmand F, Hamedi R, Yousefi M, Kafil HS. Biomed Res Int. 2020 Dec 9;2020:7279509
- Metal Nanoparticles Released from Dental Implant Surfaces: Potential Contribution to Chronic Inflammation and Peri-Implant Bone Loss. Bressan E, Ferroni L, Gardin C, Bellin G, Sbricoli L, Sivolella S, et al. Materials (Basel). 2019 Jun 25;12(12):2036.
- Evaluation of titanium ions levels in blood in patients with endosseous titanium dental implants using inductively coupled plasma mass spectrometry - a retrospective study. Vinayak R, Rosh .R .M, Praveen J. International Journal of Science and Research 2019 Vol 8(12), 115-123
- Metal elements in tissue with dental periimplantitis: a pilot study. Fretwurst T, Buzanich G, Nahles S, Woelber JP, Riesemeier H, Nelson K. Clin. Oral Impl. Res. 2016 Sep;27(9):1178-86.
- Serum Metal Levels in Maxillofacial Reconstructive Surgery Patients: A Pilot Study. Mercuri LG, Miloro M, Skipor AK, Bijukumar D, Sukotjo C, Mathew MT. J Oral Maxillofac Surg. 2018 Oct;76(10):2074-2080.
- Evaluation of serum metal ion levels in dental implant patients: A prospective study. Gopi G, Shanmugasundaram S, Krishnakumar Raja VB, Afradh KM. Ann MaxillofacSurg 2021;11:261-5.
- Titanium release in serum of patients with different bone fixation implants and its interaction with serum biomolecules at physiological levels. Nuevo-Ordóñez Y, Montes-Bayón M, Blanco-González E, Paz-Aparicio J, Raimundez JD, Tejerina JM, et al. Anal. Bioanal. Chem. 2011, 401, 2747–2754
- Analysis of serum metal ion levels in dental implant patients. Saini, R. S., &Kaur, K. (2022). International Journal of Health Sciences, 6(S5), 5645–5649.
- Exfoliative cytology and titanium dental implants: a pilot study. Olmedo DG, Nalli G, Verdú S, Paparella ML, Cabrini RL. J Periodontol. 2013 Jan;84(1):78-83.
- Evaluation of inflammatory cytokine and plasma titanium levels in dental implant treated patients. Süleyman Kiliç , Hakki Kazancioğlu , Ümit Küçüksezer , Günnur Deniz, Gülsüm Ak. Curr Res Dent Sci 2015; 24: 199-205
- Influence of fluoride, hydrogen peroxide and lactic acid on the corrosion resistance of commercially pure titanium. Mabilleau G, Bourdon S, Joly-Guillou ML, Filmon R, Baslé MF, Chappard D. ActaBiomater 2006;2:121- 129.
- Mechanism and Prevention of Titanium Particle-Induced Inflammation and Osteolysis. Eger M, Hiram-Bab S, Liron T, Sterer N, Carmi Y, Kohavi D, et al. Front. Immunol.2018; 9:2963.
- Increased Levels of Dissolved Titanium Are Associated With Peri-Implantitis - A Cross-Sectional Study. Safioti LM, Kotsakis GA, Pozhitkov AE, Chung WO, Daubert DM. J Periodontol. 2017 May;88(5):436-442. Metal concentrations in the serum and hair of patients with titanium alloy spinal implants. Kasai Y, Iida R, Uchida A. Spine (Phila Pa 1976). 2003 Jun 15;28(12):1320-6.
- Titanium release from implants prepared with different surface roughness.Wennerberg A, Ide-Ektessabi A, Hatkamata S, Sawase T, Johansson C, Albrektsson T, Martinelli A, et al. Clin Oral Implants Res. 2004 Oct;15(5):505-12.
- The effect of oral topical fluorides on the surface of commercially pure titanium. Siirila HS, Kononen M. Int J Oral Maxillofac Implants 1991;6:50-54
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