Modification of 3D Printed Denture Base Material by Hyaluronic Acid to Improve Healing

Immunohistological Effect on MMP2 and VEGF

Authors

  • Mustafa Mahmood Jasim Department of prosthodontic, College of Dentistry. University of Mosul, Mosul, Iraq
  • Amnar K. Al-Noori
  • Ghada A. Taqa

DOI:

https://doi.org/10.5195/d3000.2025.1086

Keywords:

Dentures, Prosthodontics, Hyaluronic Acid, Wound Healing, MMP2, VEGF

Abstract

Objectives: To evaluate the effect of topical release of different concentrations of hyaluronic acid from 3D printed denture bases on the healing of skin wounds. Materials and Methods: Fifteen healthy adult male rabbits from New Zealand were randomly split into three groups based on how long they would be kept: 3 days, 7 days, and 14 days. We shaved the skin on the back of each rabbit and then made five cuts in it. The wounds were sutured to allow for healing. The animals were split into three groups based on their treatment type. The first group had their wounds treated with just an incision (control negative), the second group had their incisions treated with a 3D printed specimen under the skin incision without hyaluronic acid (control positive). We added 0.25% hyaluronic acid and a 3D printed denture base specimen to the third incision, and we added 0.5% hyaluronic acid and a 3D printed denture base to the fourth incision. The fifth cut was treated with 1% HA acid and a 3D printed denture base specimen. After that, the biopsies were sent for immunohistochemistry evaluation. Results: The data from the treated group showed that hyaluronic acid (HA) speeds up healing. Conclusion: HA-treated groups, particularly those administered 0.5% and 1% concentrations, demonstrated markedly accelerated and more
comprehensive epithelial regeneration.

Downloads

Published

2025-12-12

Issue

Vol. 13 No. 1 (2025)

Section

Adults & the Elderly

License

Copyright (c) 2025 Mustafa Mahmood Jasim, Amnar K. Al-Noori, Ghada A. Taqa

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Authors who publish with this journal agree to the following terms:

  1. The Author retains copyright in the Work, where the term “Work” shall include all digital objects that may result in subsequent electronic publication or distribution.
  2. Upon acceptance of the Work, the author shall grant to the Publisher the right of first publication of the Work.
  3. The Author shall grant to the Publisher and its agents the nonexclusive perpetual right and license to publish, archive, and make accessible the Work in whole or in part in all forms of media now or hereafter known under a Creative Commons Attribution 4.0 International License or its equivalent, which, for the avoidance of doubt, allows others to copy, distribute, and transmit the Work under the following conditions:
    1. Attribution—other users must attribute the Work in the manner specified by the author as indicated on the journal Web site;
    with the understanding that the above condition can be waived with permission from the Author and that where the Work or any of its elements is in the public domain under applicable law, that status is in no way affected by the license.
  4. The Author is able to enter into separate, additional contractual arrangements for the nonexclusive distribution of the journal's published version of the Work (e.g., post it to an institutional repository or publish it in a book), as long as there is provided in the document an acknowledgement of its initial publication in this journal.
  5. Authors are permitted and encouraged to post online a prepublication manuscript (but not the Publisher’s final formatted PDF version of the Work) in institutional repositories or on their Websites prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work. Any such posting made before acceptance and publication of the Work shall be updated upon publication to include a reference to the Publisher-assigned DOI (Digital Object Identifier) and a link to the online abstract for the final published Work in the Journal.
  6. Upon Publisher’s request, the Author agrees to furnish promptly to Publisher, at the Author’s own expense, written evidence of the permissions, licenses, and consents for use of third-party material included within the Work, except as determined by Publisher to be covered by the principles of Fair Use.
  7. The Author represents and warrants that:
    1. the Work is the Author’s original work;
    2. the Author has not transferred, and will not transfer, exclusive rights in the Work to any third party;
    3. the Work is not pending review or under consideration by another publisher;
    4. the Work has not previously been published;
    5. the Work contains no misrepresentation or infringement of the Work or property of other authors or third parties; and
    6. the Work contains no libel, invasion of privacy, or other unlawful matter.
  8. The Author agrees to indemnify and hold Publisher harmless from Author’s breach of the representations and warranties contained in Paragraph 6 above, as well as any claim or proceeding relating to Publisher’s use and publication of any content contained in the Work, including third-party content.

Revised 7/16/2018. Revision Description: Removed outdated link.