Absence of history of oral cleft in first-degree relatives of patients with prostate cancer

Authors

  • Cláudia de Alvarenga Diniz Fonseca
  • Daniella Reis Barbosa Martelli
  • Ianná Luana Freitas Almeida
  • Galeno Hassen Sales
  • Rodrigo Soares de Andrade
  • Verônica Oliveira Dias
  • Letízia Monteiro de Barros
  • Hercílio Martelli Júnior

DOI:

https://doi.org/10.5195/d3000.2019.88

Keywords:

Oral clefts, cancer, prostate

Abstract

Objective: To evaluate the occurrence of nonsyndromic cleft lip and/or palate (NSCL/P) in families of patients with prostate cancer (PC).

Study design: We conducted a case-control study involving a total of 748 individuals, 280 of which had PC, and 468 were free-cancer healthy individuals. The patients answered a questionnaire with basic demographic information and family history of NSCL/P in first-degree relatives. The information collected was stored in a database and analyzed by using the statistical program SPSS® 24.0 for Windows (Chicago, IL, USA). In order to determine the association with NSCL/P, chi-square and Fisher’s exact test and odds ratio (OR) with its 95% confidence interval (95% CI) for risk magnitude assessment. Values with p<0.05 were considered statistically significant.

Results: Of total patients with PC, 2 had a positive history of NSCL/P. In the control group, 7 patients reported family history of NSCL/P (1df chi-square, p=0.34; Fisher´s exact test, p=0.49). The average age of the cases diagnosed with PC was 71.35±7.70 years, and control group was 64.42±9.67 years.

Conclusion: Despite the limited population, the frequency of NSCL/P was not significantly increased in the first-degree relatives of patients with PC. Studies with larger samples and molecular analyses are needed to better understand the possible relationships in the etiology of cancer and NSCL/P.

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Published

2019-07-25

Issue

Vol. 7 No. 1 (2019)

Section

Mechanisms of Oral Disease

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