Assessment of dentofacial variations in monozygotic twins
DOI:
https://doi.org/10.5195/d3000.2017.76Abstract
With dentofacial development being a multifactorial process, we face the question of whether genetic or environmental factors play a larger role in specific phenotypic traits. The use of twin studies allows one to employ genetic controls to the study such that one can focus solely on traits that may be more environmentally determined. This study involves retrospective as well as current analytical measurements between a set of monozygotic twins to assess genetic and outside influences on facial and intraoral development. While similarities were acknowledged, we found differences in measurements of the facial thirds, the congenital presence of mandibular third molars, and the presence of mandibular tori.
References
Horowitz SL, Osborne RH, DeGeorge FV. A cephalometric study of craniofacial variation in adult twins. Angle Orthod. 1960;30:1–5.
Cassidy KM, Harris EF, Tolley EA, Keim RG. Genetic influence on dental arch form in orthodontic patients. Angle Orthod. 1998 Oct;68(5):445-54. PubMed PMID: 9770103.
Lundström A. Nature versus nurture in dento-facial variation. Eur J Orthod. 1984 May;6(2):77-91. PubMed PMID: 6587973.
Sognnaes RF, Rawson RD, Gratt BM, Nguyen NB. Computer comparison of bitemark patterns in identical twins. J Am Dent Assoc. 1982 Sep;105(3):449-51. PubMed PMID: 6957451.
Curtner RM. Predetermination of the adult face. Am J Orthod. 1953;39:201–217
Hunter WS. A study of the inheritance of craniofacial characteristics as seen in lateral cephalograms of 72 like-sexed twins. Rep Congr Eur Orthod Soc.1965;41:59-70. PubMed PMID: 5222375.
Singh SM, Murphy B, O'Reilly R. Epigenetic contributors to the discordance of monozygotic twins. Clin Genet. 2002 Aug;62(2):97-103. Review. PubMed PMID:12220446.
Poulsen P, Esteller M, Vaag A, Fraga MF. The epigenetic basis of twin discordance in age-related diseases. Pediatr Res. 2007 May;61(5 Pt 2):38R-42R.Review. PubMed PMID: 17413848.
Fraga MF, Ballestar E, Paz MF, Ropero S, Setien F, Ballestar ML, Heine-Suñer D, Cigudosa JC, Urioste M, Benitez J, Boix-Chornet M, Sanchez-Aguilera A, Ling C, Carlsson E, Poulsen P, Vaag A, Stephan Z, Spector TD, Wu YZ, Plass C, Esteller M. Epigenetic differences arise during the lifetime of monozygotic twins. Proc Natl Acad Sci U S A. 2005 Jul 26;102(30):10604-9. PubMed PMID: 16009939; PubMed Central PMCID: PMC1174919.
Aminabadi NA, Behroozian A, Talatahari E, Samiei M, Sadigh-Eteghad S, Shirazi S. Does prenatal restraint stress change the craniofacial growth pattern of rat offspring? Eur J Oral Sci. 2016 Feb;124(1):17-25. doi: 10.1111/eos.12230. PubMed PMID: 26620628.
Kappen C. Modeling anterior development in mice: diet as modulator of risk for neural tube defects. Am J Med Genet C Semin Med Genet. 2013 Nov;163C(4):333-56. doi: 10.1002/ajmg.c.31380. Review. PubMed PMID: 24124024; PubMed Central PMCID: PMC4149464.
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