Familial inheritance of TMD: a case report

Authors

  • Maria Genello University of Pittsburgh, School of Dental Medicine

DOI:

https://doi.org/10.5195/d3000.2017.75

Keywords:

Familial TMD, systemic joint laxity, chronic headaches/pain, craniofacial dimensions, TMD inheritance

Abstract

The TMJ is a joint that can perform both hinge and sliding motions and whose proper functioning depends on the actions of the joint and joint capsule, the muscles of mastication, and the condition and action of the mandibular condyle. If any of these components deviate from their normal structure or function, then TMD can result. There have been many reported contributing factors to TMD development, many of which include environmental influences such as bruxism, trauma, and other oral habits. However, a genetic component can also play a role. This paper reports a case of TMD occurring within three consecutive generations of a family and explores the possibility of this disorder exhibiting familial inheritance. Members of the family affected all displayed manifestations of joint laxity in other areas of the body, migraines, pain, and had smaller craniofacial dimensions with a narrower mandible. These factors were found to have a genetic influence and these genes can also be tied to TMD, thus supporting the argument that the cases of TMD seen in this family are in fact due to inheritance. If TMD can be shown to have a genetic component and be inherited, then dental practitioners would be able to identify high risk patients and help to modify environmental factors early on in order to help prevent the onset of TMD in those individuals.

Author Biography

Maria Genello, University of Pittsburgh, School of Dental Medicine

I am a dental student in the graduating class of 2019 at the University of Pittsburgh School of Dental Medicine.

References

TMJ disorders. National Insti-tute of Dental and Craniofacial Re-search. [cited March 4, 2017] Available from https://www.nidcr.nih.gov/oralhealth/topics/tmj/tmjdisorders.htm#symptoms.

The many faces of the genetics contribution to temporomandibu-lar joint disorder. Oakley M, Vieira AR. Orthod Craniofac Res. 2008 Aug;11(3):125–135. PMID: 18713149.

Genetic predictors of human chronic pain conditions. Zorina-Lichtenwalter K, Meloto CB, Khoury S, Diatchenko L. Neurosci-ence. 2016 Dec;338:36–62. PMID: 27143481.

Temporomandibular joint dys-function and systemic joint laxity. Westling L. Swedish Dental Journal Supplement. 1992;81:1-79. PMID: 1621231

The role of systemic hypermo-bility and condylar hypermobility in temporomandibular joint dys-function. Kavuncu, V., Sahin, S., Kamanli, A. et al. Rheumatol Int. 2006 Jan;26(3): 257-60. PMID: 15988598

Temporomandibular disorders in relation to craniofacial dimen-sions, head posture and bite force in children selected for orthodon-tic treatment. Liselotte Sonnesen, Merete Bakke, Beni Solow. Eur J Orthod. 2001 Apr;23(2): 179-192. PMID:11398555

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Published

2017-06-16

Issue

Vol 5, No 1 (2017)

Section

Mechanisms of Oral Disease

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