Tooth malposition in patients with cleft lip and/or palate in a Brazilian population

Authors

  • Mario Rodrigues Melo Filho State University of Montes Claros - Montes Claros -Minas Gerais http://orcid.org/0000-0002-6189-2722
  • Verônica Oliveira Dias State University of Montes Claros - Montes Claros -Minas Gerais
  • Daniella Reis Martelli
  • Lívia Ribeiro Paranaíba State University of Montes Claros - Montes Claros -Minas Gerais
  • Mário Sérgio Oliveira Swerts José do Rosário Vellano University - Alfenas - Minas Gerais
  • Letízia Monteiro de Barros José do Rosário Vellano University - Alfenas - Minas Gerais
  • Hercílio Martelli Júnior State University of Montes Claros - Montes Claros -Minas Gerais José do Rosário Vellano University - Alfenas - Minas Gerais

DOI:

https://doi.org/10.5195/d3000.2015.38

Keywords:

Teeth abnormalities, cleft lip, cleft palate.

Abstract

The purpose of the present study was to evaluate the prevalence of teeth malposition (rotated) in Brazilian patients with oral clefts and to contribute to the definition of subphenotypes. This study included 317 patients with nonsyndromic cleft lip with or without cleft palate. Tooth malposition was assessed clinically, through radiographs, and medical history records for each individual. Only teeth malpositions outside the area of the clefts were included. Comparisons were assessed by cross-tabulation and standard chi-square test, and statistical significance was set at p≤0.05. Cleft lip and palate was more prevalent in males, while cleft palate was more common in females. Regarding the presence of tooth malposition, of the 317 patients, 92 (29.02%) had at least one tooth with the dental anomaly. Tooth malposition was more common in patients with cleft lip and palate (16.1%), followed by, respectively, cleft palate (6.9%) and cleft lip (6%) (p=0.112). The highest occurrence of tooth malposition was in the mandible and involved the canines (p<0.01). Few studies have investigated the prevalence of tooth malposition in individuals with nonsyndromic cleft lip with or without cleft palate. Our results confirmed the highest occurrence of dental anomalies, particularly tooth malposition, in patients with oral clefts. Our findings also highlight that there was a higher occurrence of this condition in the mandible and not the maxilla.

Author Biography

Daniella Reis Martelli

Stomatology Clinic, Dental School

References

Folate and the face: evaluating the evidence for the influence of folate genes on craniofacial development. Prescott NJ, Malcolm S. Cleft Palate Craniofac J. 2002 May;39(3):327-31. PMID: 12019010.

Cleft lip and palate: Understanding genetic and environmental influences. Dixon MJ, Marazita ML, Beaty TH, Murray JC. Nat Rev Genet. 2011 Mar;12(3):167-78. PMID: 21331089.

Prevalence of nonsyndromic oral clefts in a reference hospital in the state of Minas Gerais, Brazil, between 2000–2005. Martelli-Junior H, Porto LV, Martelli DR, Bonan PRF, Freitas AB, Coletta RD. Braz Oral Res. 2007 Oct-Dec;21(4):314-7. PMID: 18060257.

Epidemiology of Hoffmeister's “Genetically Determined Predisposition to Disturbed Development of the Dentition” in Patients with Cleft Lip and Palate. Stahl F, Grabowski R, Wigger K. Cleft Palate Craniofac J. 2006 Jul;43(4):457-65. PMID: 16854204.

Defining subphenotypes for oral clefts based on dental development. Letra A, Menezes R, Granjeiro JM, Vieira AR. J Dent Res. 2007 Oct;86(10):986-91. PMDI: 17890676.

Dental anomalies as part of the cleft spectrum. Menezes R, Vieira AR. Cleft Palate Craniofac J. 2008 Jul;45(4):414-9. PMID: 18616370.

Side of dental anomalies and taurodontism as potential clinical markers for cleft subphenotypes. Kuchler E, Motta L, Vieira A, Granjeiro J. Cleft Palate Craniofac J. 2011 Jan;48(1):103-8. PMID: 20507240.

Prevalence of Dental Anomalies in Patients With Nonsyndromic Cleft Lip and/or Palate in a Brazilian Population. Paranaíba LMR, Coletta RD, Swerts MSO. Quintino RP, Barros LM, Martelli-Júnior H. Cleft Palate Craniofac J. 2013 Jul;50(4):400-5. PMID: 21973329.

Expanding the cleft phenotype cleft l: the dental characteristics of unaffected parents of Australian children with non-syndromic lip and palate. Aspinall A, Raj S, Jugessur A, Marazita M, Savarirayan R, Kilpatrick N. Int J Paediatr Dent. 2014 Jul;24(4):286-92. PMID: 24237197.

Identification of cell patterns in human tooth differentiation. Tonge CH. J Dent Res. 1967 Sep-Oct;46(5):876-8. PMID: 5234028.

The many faces and factors of orofacial clefts. Schutte BC, Murray JC. Hum Mol Genet. 1999;8(10):1853-9. PMID: 10469837.

The origin and development of the upper lateral incisor and premaxilla in normal and cleft lip/palate monkeys induced with cyclophosphamide. Wei X, Senders C, Owiti GO, Liu X, Wei ZN, Dillard-Telm L. Cleft Palate Craniofac J. 2000 Nov;37(6):571-83. PMID: 11108527.

Abnormalities of the maxillary incisors in children with cleft lip and palate. Vichi M, Franchi L. ASDC J Dent Child. 1995 Nov-Dec;62(6):412-7. PMID: 8636477.

Dental anomalies of number in the permanent dentition of patients with bilateral cleft lip: radiographic study. da Silva AP, Costa B, de Carvalho Carrara CF. Cleft Palate Craniofac J. 2008 Sep;45(5):473-6. PMID: 8788864.

Distribution patterns of primary and permanent dentition in children with unilateral complete cleft lip and palate. Tsai TP, Huang CS, Huang CC, See LC. Cleft Palate Craniofac J. 1998 Mar;35(2):154-60. PMID: 9527312.

Prevalence and distribution of selected developmental dental anomalies in an Indian population. Gupta SK, Saxena P, Jain S, Jain D. J Oral Sci. 2011 Jun;53(2):231-8. PMID: 21712629.

Classification of cleft lip and cleft palate. Suggested changes. Spina V, Psillakis JM, Lapa FS, Ferreira MC. Rev Hosp Clin Fac Med São Paulo. 1972 Jan-Feb;27(1):5-6. PMID: 4671376.

Studies of dental anomalies in a large group of school children. Kuchler EC, Risso PA, Costa Mde C, Modesto A, Vieira AR. Arch Oral Biol. 2008 Oct;53(10):941-6. PMID: 18490001.

Prevalence of dental anomalies in a population of cleft lip and palate patients. Al Jamal GA, Hazza'a AM, Rawashdeh MA. Cleft Palate Craniofac J. 2010 Jul;47(4):413-20. PMID: 20590463.

Hypodontia in children with various types of clefts. Shapira Y, Lubit E, Kuftinec MM. Angle Orthod. 2000 Feb;70(1):16-21. PMID: 10730671.

Genetic association studies of cleft lip and/or palate with tooth hypodontia outside the cleft region. Slayton RL, Williams L, Murray JC, Wheeler JJ, Lidral AC, Nishimura CJ. Cleft Palate Craniofac J. 2003 May;40(3):274-9. PMID: 12733956.

Concomitant occurrence of canine malposition and tooth agenesis: evidence of orofacial genetic fields. Peck S, Peck L, Kataja M. Am J Orthod Dentofacial Orthop. 2002 Dec;122(6):657-60. PMID: 12490878.

Dental anomalies in children born with clefts: a case-control study. de Lima Pedro R, Faria MDB, Costa MC, Vieira AR. Cleft Palate Craniofac J. 2012 Nov;49(6):e64-e8. PMID: 21740171.

Classification and birth prevalence of orofacial clefts. Tolarová TT, Cervenka J. Am J Med Genet. 1998 Jan;75(2):126-37. PMID: 9450872.

Orofacial cleft in Southern Italy. Carinci F, Rullo R, Laino G, Festa V, Mazzarella N, Morano D, Gombos F. Minerva Stomatol. 2003 Oct;52(10):427-3. PMID: 14765027.

The genomic ancestry of individuals from different geographical regions of Brazil is more uniform than expected. Pena SD, Di Pietro G, Fuchshuber-Moraes M, Genro JP, Hutz MH, Kehdy Fde S, Kohlrausch F, Magno LA, Montenegro RC, Moraes MO, de Moraes ME, de Moraes MR, Ojopi EB, Perini JA, Racciopi C, Ribeiro-Dos-Santos AK, Rios-Santos F, Romano-Silva MA, Sortica VA, Suarez-Kurtz G. PLoS One. 2011 Feb;6(2):e17063. PMID: 21359226.

Polymorphisms at regions 1p22.1 (rs560426) and 8q24 (rs1530300) are risk markers for nonsyndromic cleft lip and/or palate in the Brazilian population. Bagordakis E, Paranaiba LM, Brito LA, de Aquino SN, Messetti AC, Martelli-Junior H, Swerts MS, Graner E, Passos-Bueno MR, Coletta RD. Am J Med Genet A. 2013 May;161A(5):1177-80. PMID: 23532876.

Polymorphisms in FGF12, VCL, CX43 and VAX1 in Brazilian patients with nonsyndromic cleft lip with or without cleft palate. de Aquino SN, Messetti AC, Bagordakis E, Martelli-Júnior H, Swerts MS, Graner E, Coletta RD. BMC Med Genet. 2013 May;14:53-6. PMID: 23679094.

Analysis of susceptibility polymorphisms for nonsyndromic cleft lip with or without cleft palate in the Brazilian population. Birth Defects. de Aquino SN, Messetti AC, Hoshi R, Borges A, Viena CS, Reis SR, Oliveira Swerts MS, Graner E, Martelli-Júnior H, Coletta RD. Res A Clin Mol Teratol. 2014 Jan;100(1):36-42. PMID: 24446087.

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Published

2015-10-23

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Section

Development of Craniofacial Structures