Effect of 0.8% High Molecular Weight Hyaluronic Acid on Soft Tissue Healing Following Third Molar Extraction

A Randomized Clinical Trial

Authors

  • Safaa Mohammed Assim University of Baghdad/ college of dentistry
  • Yassir Ryadh Al-Khannaq Department of Oral and Maxillofacial Surgery, College of Dentistry, University of Baghdad, Baghdad, Iraq https://orcid.org/0000-0002-0200-2128

DOI:

https://doi.org/10.5195/d3000.2026.1531

Keywords:

Wound Healing, Third Molar, Hyaluronic Acid, Randomized Controlled Trial, impacted

Abstract

To determine the clinical efficacy of intra-socket delivery of 0.8% HMW-hyaluronic acid in accelerating the early stages of mucosal healing after surgically extracting impacted mandibular third molars was the focus of the current study. In this double-blinded randomized clinical trial (RCT), 50 patients with impacted mandibular third molars (Pell & Gregory I-II, A-B) were assigned equally into two groups. The experimental group received 0.8% HA gel (Gengigel forte TM) via a collagen-based sponge, while the control group received a collagen-sponge only. Soft tissue healing was assessed on the seventh postoperative day using the early healing system index (EHS). The HA group yielded an overall median EHS of 7.00 (3.00 - 10.00) compared to 6.00 (2.00-10.00) in the control group. The Wilcoxon rank-sum test indicated no statistically significant difference between groups (P=0.214). Although statistical significance was not achieved, data suggested a clinical advantage of 0.8% HA in optimizing tissue healing scores. Future studies with larger sample sizes and multiple applications are recommended to verify these findings.

References

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Published

2026-09-10

Issue

Vol. 14 No. 2 (2026)

Section

Adults & the Elderly

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Copyright (c) 2026 Safaa Mohammed Assim, Yassir Ryadh Al-Khannaq

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