Absence of history of oral cleft in first-degree relatives of patients with prostate cancer

Cláudia de Alvarenga Diniz Fonseca, Daniella Reis Barbosa Martelli, Ianná Luana Freitas Almeida, Galeno Hassen Sales, Rodrigo Soares de Andrade, Verônica Oliveira Dias, Letízia Monteiro de Barros, Hercílio Martelli Júnior


Objective: To evaluate the occurrence of nonsyndromic cleft lip and/or palate (NSCL/P) in families of patients with prostate cancer (PC).

Study design: We conducted a case-control study involving a total of 748 individuals, 280 of which had PC, and 468 were free-cancer healthy individuals. The patients answered a questionnaire with basic demographic information and family history of NSCL/P in first-degree relatives. The information collected was stored in a database and analyzed by using the statistical program SPSS® 24.0 for Windows (Chicago, IL, USA). In order to determine the association with NSCL/P, chi-square and Fisher’s exact test and odds ratio (OR) with its 95% confidence interval (95% CI) for risk magnitude assessment. Values with p<0.05 were considered statistically significant.

Results: Of total patients with PC, 2 had a positive history of NSCL/P. In the control group, 7 patients reported family history of NSCL/P (1df chi-square, p=0.34; Fisher´s exact test, p=0.49). The average age of the cases diagnosed with PC was 71.35±7.70 years, and control group was 64.42±9.67 years.

Conclusion: Despite the limited population, the frequency of NSCL/P was not significantly increased in the first-degree relatives of patients with PC. Studies with larger samples and molecular analyses are needed to better understand the possible relationships in the etiology of cancer and NSCL/P.


Oral clefts; cancer; prostate; cancer

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DOI: https://doi.org/10.5195/d3000.2019.88

Copyright (c) 2019 Cláudia de Alvarenga Diniz Fonseca, Daniella Reis Barbosa Martelli, Ianná Luana Freitas Almeida, Galeno Hassen Sales, Rodrigo Soares de Andrade, Verônica Oliveira Dias, Letízia Monteiro de Barros, Hercílio Martelli Júnior

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