The effect of estrogen on craniofacial dimensions: a systematic review

Authors

  • Marjorie Ayumi Omori University of São Paulo
  • Mirian Aiko Nakane Matsumoto
  • Raquel Assed Bezerra Segato
  • Léa Assed Bezerra da Silva
  • Paulo Nelson Filho
  • Erika Calvano Kuchler

DOI:

https://doi.org/10.5195/d3000.2019.84

Keywords:

Estrogen, Craniofacial, Growth

Abstract

Sex hormones have an effect on bone metabolism. However, it remains unclear how estrogen hormone affects mandible and maxilla growth and development. The aim of this study was to perform a systematic review to evaluate if estrogen is associated with developmental alterations in the maxilla/mandible phenotype. Material and methods: A computer search of the literature was performed using: Pubmed Medline (1966 – August 2018), Google Scholar and manual searching. A combination of the terms ‘estrogens', ‘mandible’, ‘dental arch’, ‘maxilla’, ‘craniofacial’, ‘growth’ and ‘development’ was used. Studies that used animal models to evaluate the role of estrogen during growth and development on the dimensions of the maxilla and/or mandible were included. Results: 5 studies were selected to compose this systematic review. One study used zebrafish as a model. Two studies used female mice and 2 studies used female rats as a model. Two studies treated the animals with estrogen. Four studies demonstrated that estrogen has an effect on mandible dimension and 2 studies demonstrated that estrogen has an effect on maxilla. One study did find an association between estrogen deficiency and mandible/maxilla dimensions Conclusion: The current evidence suggested that both, increased and decreased levels of estrogen, have an effect on the maxilla and mandible dimensions.

References

Choi SH, Fan D, Hwang MS, Lee HK, Hwang CJ. Effect of growth hormone treatment on craniofacial growth in children: Idiopathic short stature versus growth hormone deficiency. J Formos Med Assoc. 2016.

da Fontoura CS, Miller SF, Wehby GL, Amendt BA, Holton NE, Southard TE, et al. Candidate Gene Analyses of Skeletal Variation in Malocclusion. J Dent Res. 2015;94(7):913-20.

Yoon SS, Chung CH. Comparison of craniofacial growth of untreated Class I and Class II girls from ages 9 to 18 years: a longitudinal study. Am J Orthod Dentofacial Orthop. 2015;147(2):190-6.

Sidlauskas M, Salomskiene L, Andriuskeviciute I, Sidlauskiene M, Labanauskas Z, Vasiliauskas A, et al. Heritability of mandibular cephalometric variables in twins with completed craniofacial growth. Eur J Orthod. 2016;38(5):493-502.

Pallares LF, Carbonetto P, Gopalakrishnan S, Parker CC, Ackert-Bicknell CL, Palmer AA, et al. Mapping of Craniofacial Traits in Outbred Mice Identifies Major Developmental Genes Involved in Shape Determination. PLoS Genet. 2015;11(11):e1005607.

Parada C, Chai Y. Mandible and Tongue Development. Curr Top Dev Biol. 2015;115:31-58.

Lorenzo J. A new hypothesis for how sex steroid hormones regulate bone mass. J Clin Invest. 2003;111(11):1641-3.

Ben-Hur H, Mor G, Blickstein I, Likhman I, Kohen F, Dgani R, et al. Localization of estrogen receptors in long bones and vertebrae of human fetuses. Calcif Tissue Int. 1993;53(2):91-6.

Fujita T, Ohtani J, Shigekawa M, Kawata T, Kaku M, Kohno S, et al. Effects of sex hormone disturbances on craniofacial growth in newborn mice. J Dent Res. 2004;83(3):250-4.

Singh IJ, Gunberg DL. Effect of estrogen treatment on bone cortex of the young rat. Anat Rec. 1971;171(2):273-82.

Seifi M, Ashiri M, Hedayati M. Effect of sexual hormone elimination on the changes of craniofacial dimensions in rats. Journal of Dental School Shahid Beheshti University of Medical Sciences. 2008;25(4):365-72.

Marquez Hernandez RA, Ohtani J, Fujita T, Sunagawa H, Kawata T, Kaku M, et al. Sex hormones receptors play a crucial role in the control of femoral and mandibular growth in newborn mice. Eur J Orthod. 2011;33(5):564-9.

Fushimi S, Wada N, Nohno T, Tomita M, Saijoh K, Sunami S, et al. 17beta-Estradiol inhibits chondrogenesis in the skull development of zebrafish embryos. Aquat Toxicol. 2009;95(4):292-8.

Mizuno Y, Hosoi T, Inoue S, Ikegami A, Kaneki M, Akedo Y, et al. Immunocytochemical identification of androgen receptor in mouse osteoclast-like multinucleated cells. Calcif Tissue Int. 1994;54(4):325-6.

Bellido T, Jilka RL, Boyce BF, Girasole G, Broxmeyer H, Dalrymple SA, et al. Regulation of interleukin-6, osteoclastogenesis, and bone mass by androgens. The role of the androgen receptor. J Clin Invest. 1995;95(6):2886-95.

Riggs BL, Melton LJ, 3rd. Involutional osteoporosis. N Engl J Med. 1986;314(26):1676-86.

Turner AS, Alvis M, Myers W, Stevens ML, Lundy MW. Changes in bone mineral density and bone-specific alkaline phosphatase in ovariectomized ewes. Bone. 1995;17(4 Suppl):395S-402S.

Harris B, Lovett L, Smith J, Read G, Walker R, Newcombe R. Cardiff puerperal mood and hormone study. III. Postnatal depression at 5 to 6 weeks postpartum, and its hormonal correlates across the peripartum period. Br J Psychiatry. 1996;168(6):739-44.

Yamashiro T, Takano-Yamamoto T. Influences of ovariectomy on experimental tooth movement in the rat. J Dent Res. 2001;80(9):1858-61.

Haruyama N, Igarashi K, Saeki S, Otsuka-Isoya M, Shinoda H, Mitani H. Estrous-cycle-dependent variation in orthodontic tooth movement. J Dent Res. 2002;81(6):406-10.

Gennari L, Merlotti D, De Paola V, Calabro A, Becherini L, Martini G, et al. Estrogen receptor gene polymorphisms and the genetics of osteoporosis: a HuGE review. Am J Epidemiol. 2005;161(4):307-20.

Howe K, Clark MD, Torroja CF, Torrance J, Berthelot C, Muffato M, et al. The zebrafish reference genome sequence and its relationship to the human genome. Nature. 2013;496(7446):498-503.

Waterston RH, Lindblad-Toh K, Birney E, Rogers J, Abril JF, Agarwal P, et al. Initial sequencing and comparative analysis of the mouse genome. Nature. 2002;420(6915):520-62.

Lander ES, Linton LM, Birren B, Nusbaum C, Zody MC, Baldwin J, et al. Initial sequencing and analysis of the human genome. Nature. 2001;409(6822):860-921.

Gibbs RA, Weinstock GM, Metzker ML, Muzny DM, Sodergren EJ, Scherer S, et al. Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Nature. 2004;428(6982):493-521.

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Published

2019-06-26

Issue

Vol. 7 No. 1 (2019)

Section

Development of Craniofacial Structures

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