Could recurrent aphthous stomatitis be linked to cancer development?

Autori

  • Emily Norton University of Pittsburgh, School of Dental Medicine

DOI:

https://doi.org/10.5195/d3000.2017.66

Parole chiave:

recurrent aphthous stomatitis, cancer, TNF-alpha

Abstract

Background: Recurrent aphthous stomatitis is a common multifactorial oral mucosal disorder. Genetic and local factors causing RAS may contribute to the development of cancer. This study aims to explore this connection by examining a family with a history of RAS and ovarian cancer.  Case Description: The family described in the case exhibits a history of minor recurrent aphthous stomatitis. The severity of this condition increases with each generation. One member of the family has no history of RAS but was diagnosed with ovarian cancer. Genetic testing for BRCA mutations was negative indicating a different genetic cause of the cancer. All affected members of the family indicate high levels of stress or difficulty responding to stressful situations. No treatment for RAS was performed due to its self-limiting nature.  Practical Implications: Further research is needed before dentists begin to tell their patients with RAS they may be at higher risk of developing cancer. Diligent oral cancer screening and stress management counseling can decrease the risk to the patient.

Riferimenti bibliografici

Nasry SA, El Shenawy HM, Mostafa D, Ammar NM. Different modalities for treatment of recurrent aphthous stomatitis. A Randomized clinical trial. J Clin Exp Dent. 2016 Dec 1;8(5):e517-e522. eCollec-tion 2016 Dec. PubMed PMID: 27957263; PMCID: PMC5149084.

Najafi S, Mohammadzadeh M, Zare Bidoki A, Meighani G, Aslani S, Mahmoudi M, Rezaei N. HLA-DRB and HLA-DQB Allele and Haplo-type Frequencies in Iranian Patients with Recurrent Aphthous Stomatitis. Iran J Allergy Asthma Immunol. 2016 Aug;15(4):289-295. PMID: 27921409.

Han M, Fang H, Li QL, Cao Y, Xia R, Zhang ZH. Effec-tiveness of Laser Therapy in the Management of Re-current Aphthous Stomati-tis: A Systematic Review. Scientifica (Cairo). 2016;2016:9062430. doi: 10.1155/2016/9062430. Epub 2016 Dec 18. Review. PubMed PMID: 28078164; PMCID: PMC5203897.

Ślebioda Z, Krawiecka E, Rozmiarek M, Szponar E, Kowalska A, Dorocka-Bobkowska B. Clinical phe-notype of recurrent aph-thous stomatitis and inter-leukin-1β genotype in a Polish cohort of patients. J Oral Pathol Med. 2016 Dec 9. doi: 10.1111/jop.12533. [Epub ahead of print] PMID: 27935125.

Yigit S, Tekcan A, Rustemo-glu A, Tumer MK, Kalkan G, Yerliyurt K. Investigation of CD40 gene rs4810485 and rs1883832 mutations in patients with recurrent aphthous stomatitis. Arch Oral Biol. 2017 Feb;74:51-54. doi: 10.1016/j.archoralbio.2016.11.003. Epub 2016 Nov 5. PMID: 27875792.

Zhang JM, An J. Cytokines, inflammation, and pain. Int Anesthesiol Clin. 2007 Spring;45(2):27-37. Re-view. PubMed PMID: 17426506; PMCID: PMC2785020.

Esposito E, Cuzzocrea S. TNF-alpha as a therapeutic target in inflammatory dis-eases, ischemia-reperfusion injury and trauma. Curr Med Chem. 2009;16(24):3152-67. PMID: 19689289.

Gallo Cde B, Mimura MA, Sugaya NN. Psychological stress and recurrent aph-thous stomatitis. Clinics (Sao Paulo). 2009;64(7):645-8. doi: 10.1590/S1807-59322009000700007. PubMed PMID: 19606240; PMCID: PMC2710437.

Chida Y, Hamer M, Wardle J, Steptoe A. Do stress-related psychosocial fac-tors contribute to cancer incidence and survival? Nat Clin Pract Oncol. 2008 Aug;5(8):466-75. doi: 10.1038/ncponc1134. Epub 2008 May 20. Review. PMID: 18493231.

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Pubblicato

2017-06-08

Fascicolo

Sezione

Mechanisms of Oral Disease