Absence of history of oral cleft in first-degree relatives of patients with prostate cancer

Συγγραφείς

  • Cláudia de Alvarenga Diniz Fonseca
  • Daniella Reis Barbosa Martelli
  • Ianná Luana Freitas Almeida
  • Galeno Hassen Sales
  • Rodrigo Soares de Andrade
  • Verônica Oliveira Dias
  • Letízia Monteiro de Barros
  • Hercílio Martelli Júnior

DOI:

https://doi.org/10.5195/d3000.2019.88

Λέξεις-κλειδιά:

Oral clefts, cancer, prostate

Περίληψη

Objective: To evaluate the occurrence of nonsyndromic cleft lip and/or palate (NSCL/P) in families of patients with prostate cancer (PC).

Study design: We conducted a case-control study involving a total of 748 individuals, 280 of which had PC, and 468 were free-cancer healthy individuals. The patients answered a questionnaire with basic demographic information and family history of NSCL/P in first-degree relatives. The information collected was stored in a database and analyzed by using the statistical program SPSS® 24.0 for Windows (Chicago, IL, USA). In order to determine the association with NSCL/P, chi-square and Fisher’s exact test and odds ratio (OR) with its 95% confidence interval (95% CI) for risk magnitude assessment. Values with p<0.05 were considered statistically significant.

Results: Of total patients with PC, 2 had a positive history of NSCL/P. In the control group, 7 patients reported family history of NSCL/P (1df chi-square, p=0.34; Fisher´s exact test, p=0.49). The average age of the cases diagnosed with PC was 71.35±7.70 years, and control group was 64.42±9.67 years.

Conclusion: Despite the limited population, the frequency of NSCL/P was not significantly increased in the first-degree relatives of patients with PC. Studies with larger samples and molecular analyses are needed to better understand the possible relationships in the etiology of cancer and NSCL/P.

Αναφορές

Fitzmaurice C, Allen C, Barber R. Global, regional, and national cancer incidence, mortality, years of life lost, years lived with disability, and disability-adjusted life-years for 32 cancer groups, 1990 to 2015: a systematic analysis for the global burden of disease study. JAMA Oncol. 2017; (3):524-548.

Siegel RL, Miller KD, Jemal A. Cancer Statistics, 2017. CA Cancer J Clin [Internet]. 2017;67(1):7–30. Available from: http://www.ncbi.nlm.nih.gov/pubmed/28055103

INCA. The National Cancer Institute. Cancer statistic. Brazil:INCA, 2017. Retrieved from: http://www.inca.gov.br/estimativa/2018/estimativa-2018.pdf.

Dixon MJ, Marazita ML, Beaty TH, Murray JC. Cleft lip and palate: understanding genetic and environmental influences. Nat Rev Genet. 2011;(12):167-178.

Martelli-Junior H, Porto LV, Martelli DR, Bonan PR, Freitas AB, Coletta RD. Prevalence of nonsyndromic oral clefts in a reference hospital in the state of Minas Gerais, Brazil, between 2000-2005. Braz Oral Res. 2007;(21):314-317.

Rodrigues K, Sena MFD, Roncalli AG, Ferreira MAF. Prevalence of orofacial clefts and social factors in Brazil. Braz Oral Res. 2009;(23):38-42.

Meng L, Bian Z, Torensma R, Von DenHoff JW. Biological mechanisms in palatogenesis and cleft palate. J Dent Res. 2009;(88):22–33.

Martelli DR, Vieira AR, Fonseca AT, Coletta RD, Soares PB, Martelli-Júnior H. Risk of nonsyndromic cleft lip and palate in relatives of women with breast cancer. Am J MedGenet. 2014;(164):270-271.

Machado RA, de Freitas EM, de Aquino SN, Martelli DR, Swerts MS, Reis SR, et al. Clinical relevance of breast and gastric cancer-associated polymorphisms as potential susceptibility markers for oral clefts in the Brazilian population. BMC Med Genetics. 2017;(5):18:39.

Sabóia TM, Reis MF, Martins ÂMC, Romanos HF, Tannure PN, Granjeiro JM, et al. DLX1 and MMP3 contribute to oral clefts with and without positive family history of cancer. Arch Oral Biol. 2015;60(2):223–8.

Steinwachs EF, Amos C, Johnston D, Mulliken J, Stal S, Hecht JT. Nonsyndromic cleft lip and palate is not associated with cancer or other birth defects. Am J Med Genet. 2000;(90):17-24.

Nishi M, Miyake H, Takeda T, Hatae Y. Congenital malformations and childhood cancer. Med Pediatr Oncol. 2000;(34):250-254.

Zhu JL, Basso O, Hasle H, Winther JF, Olsen JH, Olsen J. Do parents of children with congenital malformations have a higher cancer risk? A nationwide study in Denmark. Br J Cancer. 2002;(87):524-528.

Menezes R, Marazita ML, Goldstein McHenry T, Cooper ME, Bardi K, Brandon C, et al. AXIS inhibition protein 2, orofacial clefts and a family history of cancer. J Am Dent Assoc. 2009;(140):80-84.

Vieira AR, Khaliq S, Lace B. Risk of cancer in relatives of children born with isolated cleft lip and palate. Am J Med Genet A. 2012;(158):1503-1504.

Jindal A, Vieira AR. Family history of cleft lip and palate in subjects diagnosed with leukemia. Am J Med Genet A. 2012;(158):678-679.

Kluijt I, Sijmons RH, Hoogerbrugge N, Plukker JT, De Jong D, Van Krieken JH, et al. Familial gastric cancer: guidelines for diagnosis, treatment and periodic surveillance. Fam Cancer. 2012;(11):363-369.

Dietz A, Pedersen DA, Jacobsen R, Wehby GL, Murray JC, Christensen K. Risk of breast cancer in families with cleft lip and palate. Ann Epidemiol. 2012;(22):37-42.

Yildirim M, Seymen F, Deeley K, Cooper ME, Vieira AR. Defining predictors of cleft lip and palate risk. J Dent Res. 2012;(91):556-561.

Lima LS, Silvério Mde O, Swerts MS, Aquino SN, Martelli DR, Martelli-Júnior H. Frequency of cancer in first-degree relatives of patients with cleft lip and/or palate in the Brazilian population. Braz Dent J. 2013;(24):200-203.

Benusiglio PR, Caron O, Consolino E, Duvillard P, Coulet F, Blayau M, et al. Cleft lip, cleft palate, hereditary diffuse gastric cancer and germline mutations in CDH1. Int J Cancer. 2013;(132): 2466-2470.

Gonçalves E, Martelli DR, Coletta RD, Vieira AR, Caldeira AP, MartelliJúnior H. Risk of leukemia in first degree relatives of patients with nonsyndromic cleft lip and palate. Braz Oral Res. 2014;(28):1-3.

Hozyasz KK, Mostowska A, Wójcicki P, Lasota A, Offert B, Balcerek A, et al. Nucleotide variants of the cancer predisposing gene CDH1 and the risk of non-syndromic cleft lip with or without cleft palate. Fam Cancer. 2014;(13):415-421.

Bui AH, Ayub A, Ahmed MK, Taioli E, Taub PJ. Association Between Cleft Lip and/or Cleft Palate and Family History of Cancer: A Case-Control Study. Ann Plast Surg. 2018;(80):178-181.

Cardoso EF, Martelli DR, Machado RA, Coletta RD, de Souza JD, Barbosa FTet al. Nonsyndromic cleft lip and palate, gastric cancer and tooth agenesis. Med Oral Patol Oral Cir Bucal. 2018;(23):44-48.

IBGE - Instituto Brasileiro de Geografia e Estatística. Estimativas de população – IBGE, 2018. Retrieved from: https://www.ibge.gov.br.

Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, et al. Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer. 2015;(136):359-386.

Ferlay J, Soerjomataram I, Ervik M, Dikshit R, Eser S, Mathers C, et al. GLOBOCAN, cancer incidence and mortality worldwide: IARC CancerBase, Lyon, France: International Agency for Research on Cancer. 2013;(1) 46-50.

Taioli E, Ragin C, Robertson L, Linkov F, Thurman N E, Vieira A R. Cleft Lip and Palate in Family Members of Cancer Survivors. Cancer Invest. 2010 November; 28(9): 958–962.

Dunkhase E, Ludwig KU, Knapp M, Skibola CF, Figueiredo JC, Julie F, et al. Genomics Data Nonsyndromic cleft lip with or without cleft palate and cancer: Evaluation of a possible common genetic background through the analysis of GWAS data. Genomics Data. 2016;(10):22–9.

Rossi MR, Hawthorn L, Platt J, Burkhardt T, Cowell JK, Ionov Y. Identification of inactivating mutations in the JAK1, SYNJ2, and CLPTM1 genes in prostate cancer cells using inhibition of nonsense-mediated decay and microarray analysis. Cancer Genet Cytogenet. 2005;161(2):97–103.

Barros MS, Silva VR, Santos GB, Hughes A, Silveira MA. Prevalence of prostate adenocarcinoma according to race in an university hospital. Int Braz J Urol. 2003;(29): 306-11.

Glina S, Toscano-Júnior IL, Mello LF, Martins FG, Vieira VLA, Damas CGS. Results of screening for prostate cancer in a community hospital. Brazilian J Urol. 2001;27(3):235–43.

Romero FR, Romero AW, de Almeida RMS, Filho RT. The prevalence of prostate cancer in Brazil is higher in Black men than in White men: Systematicreview and meta-analysis. Int Braz J Urol. 2012;38(4):440–7.

Pena SDJ, Di Pietro G, Fuchshuber-Moraes M, Genro JP, Hutz MH, Kehdy FSG et al. The genomic ancestry of individuals from different geographical regions of Brazil is more uniform than expected. PloS One. 2011; 6(2)

Λήψεις

Δημοσιευμένα

2019-07-25

Τεύχος

Ενότητα

Mechanisms of Oral Disease