Effect of Potassium Iodide and Glutathione on Color Change and Remineralization Potential Induced by Silver Diamine Fluoride Application





Silver diamine fluoride, Remineralization, Discoloration, Potassium iodide, Glutathione


Purpose: To evaluate the effect of applying potassium-iodide (KI) and glutathione (GSH) on silver-diamine fluoride (SDF) induced tooth discoloration as well as their effect on its remineralization potential.

Methods: To examine color change, cervical dentinal demineralized cavities were performed mesially and distally in 16 human premolars. Glass-ionomer restoration (GIC) was applied and allocated to four groups I-IV according to the following pre-treatments: No pre-treatment, SDF, SDF+KI, SDF+20%(wt) GSH. Spectrophotometric evaluation of samples at time intervals: 1,7 and 14 days of GIC application. To examine the effect of remineralization, 21 bovine dentin blocks were divided into groups I-III: SDF, SDF + KI, and SDF + GSH. Vickers microhardness was measured, before and after demineralization and after 7 days of treatment.

Results: Spectrophotometric results after 14 days for groups I-IV were:1.29±0.18, 12.24±0.19, 2.19±0.32 and 4.76±0.19 respectively. Groups III and IV showed significant reduction in ΔE compared with group II, although they showed significant increase in ΔE compared with group I (p<0.001). KI showed better management of color changes than GSH. The microhardness test results after treatment application to demineralized dentin for Groups I-III were: 30.81±20.87, 30.59±16.42, 24.69±13.21, respectively. All groups showed significantly increased microhardness of demineralized dentin (P ≤ 0.05), which was comparable to that of Group I.

Conclusion: Application of KI and GSH after SDF significantly minimized color changes without affecting the remineralizing effect of SDF.

Author Biographies

Salma Mohammed ElSabaa

Biomaterials Department, Faculty of Dentistry Ain Shams University

Ahmed El Banna

Biomaterials Department, Faculty of Dentistry Ain Shams University

Dina Ahmed El Refai

Biomaterials Department, Faculty of Dentistry Ain Shams University


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